师资队伍

新药设计、合成及生物活性研究

王瑞嘉

2020年06月11日 17:06  点击:[]

王瑞嘉:2017年获得湖南大学有机化学博士学位。

研究方向:有机合成方法学。

科学贡献:

研究成果:

1.以单质碘为催化剂,完成喹啉氮氧的磺酰化反应

2.以高价碘为氧化剂合成多卤2-氢吡咯

3.以高价碘为氧化剂合成(E)-卤代噁唑烷

荣誉和奖项

代表性论文:

1.Ruijia Wang, Jiannan Xiang*, Wei Deng, Jin-Heng Li*et al. “PhI(OAc)2-Mediated 1,2-Haloamination of Alkynes: A Facile Access to 4-(Halomethylene)oxazolidin-2-ones”.Org. Biomol. Chem.2017, 15, 3964–3967.

2.Ruijia Wang,Zebing Zeng, Zhong Cao, Wei Deng*, Jiannan Xiang*et al.Fast Regioselective Sulfonylation of Pyridine/QuinolineN-Oxides Induced by Iodine”,Org. Biomol. Chem.2016.14.5317-5321.

3.Ruijia Wang, Yuejun OuYang, Wei Deng, Zebing Zeng,Jiannan Xiang*et al.“Hypervalent Iodine-Triggered Transformation of Homopropargyl Sulfonamides into Dihalo-2,3-dihydropyrroles”Org. Biomol. Chem .2017,15, 796 – 800

4.Menghua Zhu, De Chen, Sheng Zeng, Chenhu Xing, Wei Deng, Jiannan Xiang*,Rui-Jia Wang*. “Synthesis of (Z)-nitroalkene derivatives through oxidative dehydrogenation coupling ofa-aminocarbonyl compounds with nitromethane by copper catalysis”Tetrahedron Letters59. (2018). 3214–3219

5.Niannian Yi,Ruijia Wang,Wenqiang Fu,Weimin He*et al.“Copper/Iron-Catalyzed Aerobic Oxyphosphorylation of Terminal Alkynes Leading to β-Ketophosphonate”J. Org. Chem.2015. 80. 5023-5029.

6.Jiannan Xiang,Rui Yuan,Ruijia Wang,Weimin He*et al.“Method for Transforming Alkynes into (E)-Dibromoalkenes”J. Org. Chem.2014.79.11378-11382.

7.Longyong Xie, Rui Yuan,Ruijia Wang, Zhihong Peng, Jiannan Xiang,* Weimin He*.“Gold(I)-Catalyzed Hydration of Alkynylphosphonates: Efficient Access to β-Ketophosphonates”Eur. J. Org. Chem.2014, 2668–2671.

8.Jiannan Xiang, Niannian Yi, Ruijia Wang, Weimin He*et al. “Synthesis of β-ketophosphonates via AgNO3-catalyzed hydration of alkynylphosphonates: a rate-enhancement effect of methanol”Tetrahedron. 2015, 694–699.

9.Jun Jiang, Yundong Wu,Ruijia Wang, Wei Deng, Zebing Zeng, Jiannan Xiang*et al. “A direct catalyst-free and stereoselective sulfonylation of propargyl esters for efficient synthesis of (Z)-β-sulfonyl enoates in water”.Tetrahedron. 2016, 7895-7900.

10.Niannian Yi, Hao Zhang, Chonghui Xu, Wei Deng,*Ruijia Wang,Jiannan Xiang*et al.“Copper/Silver Cocatalyzed Oxidative Coupling of Vinylarenes with ICH2CF3or ICH2CHF2Leading to β CF3/CHF2 Substituted Ketones”Org. Lett.2016, 18, 1780−1783.

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