王炜
邮箱wangwei402@hotmail.com
王炜，湖南省芙蓉学者特聘教授，博导，湖南中医药大学药学院副院长，创新药物研究所副所长。Karachi University、陕西中医药大学、西南民族大学、湖南医药学院等客座职教授或特聘专家，柳州市政府顾问。
主持国家自然科学基金、国家863课题和国际合作课题多项。先后在国内外期刊发表SCI论文100余篇。获授权专利6项。
担任Bentham Science国际期刊Current Traditional Medicine执行主编；Current Medicinal Chemistry(影响因子3.8),Current Cancer Drug Target (影响因子3.5), Current Molecular Medicine（影响因子3.6）,Current Alzheimer Research（影响因子3.8）的编委；Journal of Natural Products、Phytomedicine、Bioorganic & Medicinal Chemistry Letters等30多家SCI专业杂志的审稿人。
1.研究方向
中药药效物质基础研究
活性分析新方法的建立
药物筛选新方法研究
2.科学贡献
近五年共发表70篇SCI论文，影响因子（IF）10分以上4篇，其中通讯作者2篇（Journal of Pineal Research, 2018;65:e12478. IF: 15.221；Biomaterials. 2019, 217, 119301. IF: 10.273），共同第一作者1篇(Angewandte Chemie-International Edition. doi.2019, 10.1002/anie.201903683. IF: 12.257)，第四作者1篇(Journal of The American Chemical Society, 2019, 141(2), 1126-1134. IF: 14.695)，IF>6有10篇，IF>3分有33篇，授权专利7项。
在中药药效物质基础研究领域成果：（1）新活性物质基础的发现，申请人对30个中药和湖南民族药品种进行了深入物质基础研究，发现了208个新化合物，176个新活性化合物，包括新颖的香豆木脂素，碳甲基黄酮烯，三聚体呫吨酮苷等骨架，发表在Journal of Natural Products（2016, 79，3079）和Phytochemistry（2018, 145, 85）等杂志；（2）活性分析新方法的建立，基于中药和民族药物化学成分的多样性的基础上，开展了活性多样性分析，建立了一系列快速、灵敏、高效的活性分析方法，发表在Analytical Chemistry, 2018, 90, 2655；2017，89，11014，IF:6.350，Biosensors & Bioelectronic, 2017, 90: 103–109. IF：9.518和Talanta, 2019, 204, 20-28.等杂志；（3）药物筛选新方法研究，寻找活性成分的特异性作用靶点，探索作用机制，建立新的药物筛选方法，发表在Journal of Pineal Research（2018;65:e12478），Angewandte Chemie-International Edition（2019, doi.10.1002/anie.201903683），Sensors and Actuators B-Chemical（2019，291，85–492. IF: 6.393）和ACS Sensors（2018, 3, 1727−1734. IF :6.944）；（4）中药活性成分靶向增效研究，如蟾毒它灵等，利用生物材料进行分子靶向修饰提高药效，发表在Biomaterials（2019, 217, 119301）和Nanomedicine2019, doi.10.2217/nnm-2018-0378）。
3.荣誉和奖项
2004:湖南省中医药科技三等奖，合作项目名称：血管性痴呆瘀阻脑络证机理及活血通络为主干预的临床与实验研究，奖励编号2004009。
2005：湖南省科技进步二等奖，合作项目名称：宫环出血病证治体系构建与中药干预效应的研究，证书号：2005260127-2-07。
2017:四川省科技进步奖三等奖，合作项目名称：道地特色民族药防治重大疾病的综合利用与开发。
4.代表性论文
1.Jing Ning#,Wei Wang#, Guangbo Ge#, Peng Chu, Feida Long, Yongliang Yang,* Yulin Peng, Lei Feng,* Xiaochi Ma*, and Tony D. James. Targeted Enzyme Activated Two-Photon Fluorescent Probes: A Case Study of CYP3A4 Using a Two-Dimensional Design Strategy.Angewandte Chemie-International Edition. 2019, 10.1002/anie.201903683.IF: 12.257
2.Bin Liu, Wenmiao Wang, Jialong Fan, Ying Long, Feng Xiao, Muhammad Daniyal,Chunyi Tong, Qian Xie, Yuqing Jian, Bin Li, Xiaochi Ma*,Wei Wang*.RBC membrane camouflaged prussian blue nanoparticles for gamabutolin loading and combined chemo/photothermal therapy of breast cancer.Biomaterials.2019, 217, 119301.IF: 10.273
3.Jing Ning#, Tao Liu#, Peipei Dong#,Wei Wang, Guangbo Ge, Bo Wang, Zhenlong Yu, Lei Shi, Xiangge Tian, Xiaokui Huo, Lei Feng*, Chao Wang, Chengpeng Sun, Jing-Nan Cui, Tony D. James, and Xiaochi Ma*.Molecular design strategy to construct the near-infrared fluorescent probe for selectively sensing human cytochrome P450 2J2.Journal ofTheAmerican Chemical Society,2019, 141(2), 1126-1134. DOI: 10.1021/jacs.8b12136.IF:14.695
4.Yan Qin, Muhammad danial, Wenmiao Wang,Yuqing Jian,Wei Yang, Yixing Qiu, Chunyi Tong,Wei Wang*, Bin Liu*, An Enhanced Silver Nanocluster System for Cytochrome c Detection and Natural Drug Screening targeted for Cytochrome c.Sensors and Actuators B-Chemical.291(2019)485–492.IF:6.393
5.Shumaila Tasneem, Bin Li, M Iqbal Choudhary,Wei Wang*, Molecular Pharmacology of Inflammation:Medicinal Plants as Anti-Inflammatory Agents.Pharmacological Research. 2019,139, 126–140.IF：5.574
6.Zhenlong Yu#, Xiangge Tian#, Yuling Peng#, Zheng Sun, Chao Wang, Ning Tang, Bin Li, Yuqing Jian,Wei Wang*, Xiaokui Huo and Xiaochi Ma*,Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin-induced apoptosis in neural cancer cells.Journal of Pineal Research,2018;65:e12478.DOI:10.1111/jpi.12478.IF:15.221
7.Lei Feng#, Yongliang Yang#, Xiaokui Huo#, Xiangge Tian#, Yujie Feng, Hanwen Yuan, Lijian Zhao, Chao Wang*, Peng Chu, Feida Long,Wei Wang*, and Xiaochi Ma*,Highly selective NIR probe for intestinal β-Glucuronidase and High-throughput screening inhibitors to therapy intestinal damage.ACS Sensors, 2018,3, 1727−1734.IF:6.944
8.Chunyi Tong#,Chuan Zhao#,Bin Liu*,Bin Li,Zhaoyang Ai,Jialong Fan, andWei Wang*, Sensitive Detection of RNase A Activity and Collaborative Drug Screening Based on rGO and Fluorescence Probe.Analytical Chemistry, 2018,90 (40), 2655-2661.IF:6.350
9.Chunyi Tong#, Xizhi Zhang#, Jialong Fan, Bin Li, Bin Liu*, Daniyal Muhammad,Wei Wang*. PEGylated mBPEI-rGO nanocomposites facilitate hepotocarcinoma treatment combining photothermal therapy and chemotherapy.Science Bulletin, 2018, 10.1016/j.scib.2018.06.003.IF:6.277
10.Yang Liu, Jianping Zhao, Yang Chen, Wei Li, Bin Li, Yuqing Jian, Gulnar Sabir, Shaowu Cheng, Qinhui Tuo, Ikhlas Khan, andWei Wang*. Polyacetylenic Oleanane-Type Triterpene Saponins from the Roots ofPanax japonicus.Journal of Natural Products, 2016, 79 (12):3079-3085. IF：4.257
